From: Subject: Date: Wed, 14 Jan 2009 21:17:17 -0000 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C9768D.7A5D7020" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.2962 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C9768D.7A5D7020 Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable Content-Location: http://view.adapubs.adamail.org/?j=fe8e1374756500757c&m=fef61079726005&ls=fe1e1d70726d0d79741175 =EF=BB=BF

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Please note: The eGRAM = email=20 publication sent earlier this morning = did not=20 include a link to the Expert Panel=20 Recommendations prepared by the Council = on=20 Scientific Affairs.

This link has been = added to the=20 Quick Links section on the right, as = well as=20 within the original copy below. This = updated=20 version has been prepared to ensure that = our=20 members and constituents are equipped = with the=20 most accurate and complete information=20 available.

JADA Study on = Oral=20 Bisphosphonates Receives Widespread = Media=20 Attention

The authors of a study = published=20 in the January issue of The Journal of the = American Dental=20 Association (JADA) on oral=20 bisphosphonates and osteonecrosis of the = jaw=20 (ONJ) reported that oral use of = alendronate (a=20 bisphosphonates drug) appears to have=20 contributed to ONJ in a subset of = patients after=20 certain dental procedures were = performed. Oral=20 bisphosphonate drugs are commonly = prescribed for=20 people with osteoporosis.

The University of = Southern=20 California, where the lead researcher is = based,=20 issued a press release about the study's = findings, which generated significant = media=20 interest, including an article in the = Los Angeles = Times.

The following points and = ADA=20 resources should be helpful should your = patients=20 inquire about oral bisphosphonate = therapy and=20 ONJ. A patient handout on = this topic=20 is available for free download on = ADA.org. In=20 addition, the Council on Scientific = Affairs has=20 published a report containing=20 recommendations for treatment of dental = patients=20 who are taking oral bisphosphonates.

Patient = Communication=20 Points

  • Osteonecrosis of the = jaw (ONJ) is=20 not common, but it can be a serious = condition=20 that can cause severe destruction of=20 jawbones.
  • The American Dental = Association=20 has reviewed previous studies on this = issue=20 which indicate that use of oral = bisphosphonates=20 (medication commonly prescribed for = patients=20 with osteoporosis) has been associated = with a=20 low risk for developing ONJ-one study = indicated=20 1 out of 2,260 people taking oral=20 bisphosphonates develop ONJ. This new = study from=20 USC claims that the frequency of ONJ = among oral=20 bisphosphate users is higher than = previously=20 reported-approximately 4 percent of the = people=20 studied.
  • It is worth noting that = this new=20 study involved a small number of people, = and the=20 study results may not apply to all = people on=20 oral bisphosphonate therapy. The = American Dental=20 Association believes that additional = research is=20 needed: to better define the risks of = ONJ; to=20 better understand how to prevent ONJ; = and to=20 better treat ONJ when it occurs. =
  • The ADA has been = monitoring=20 research on this issue for some time and = published a report containing=20 recommendations for dentists who treat = patients=20 who are taking oral bisphosphonates. =
  • It's important for me = to know if=20 you are on bisphosphonate drugs or if = you've=20 used them in the past because of the = possible=20 risk of developing ONJ. ONJ is uncommon, = but it=20 can be serious. If you have received=20 bisphosphonate therapy = intravenously=20 related to cancer therapy, you may be at = a=20 higher risk of developing ONJ than if = you take=20 oral medication. 
  • Current ADA = recommendations=20 suggest that routine dental treatment = generally=20 need not be altered merely because a = patient is=20 taking or has taken oral = bisphosphonates.=20 However, patients with any history of=20 bisphosphonate therapy should be = especially=20 encouraged to practice optimal oral = hygiene and=20 to receive routine dental examinations.=20 Furthermore, a comprehensive oral = examination=20 and treatment before or soon after = commencing=20 bisphosphonates therapy may be = beneficial for=20 patients if they're not already = receiving=20 regular dental care to treat existing = oral=20 health problems.
  • If you'd like more = information=20 about this or any other oral health = topic, be=20 sure to visit the American Dental = Association's=20 Web site at ADA.org.
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